Pertussis (Whooping Cough)

CDC Pink Book on Pertussis
http://www.cdc.gov/vaccines/pubs/pinkbook/downloads/pert.pdf

Package Inserts (DTaP, Tdap)
(DTaP- ages 2 months to 6 years)
http://www.immunize.org/packageinserts/pi_diphtheria.asp
(Tdap- ages 7 and up)
http://www.immunize.org/packageinserts/pi_tdap.asp

Pertussis Information
http://www.nvic.org/Vaccines-and-Diseases/Whooping-Cough.aspx

Pertussis Surveillance and Reporting
http://www.cdc.gov/pertussis/surv-reporting.html

Pertussis frequently asked questions
http://www.cdc.gov/pertussis/about/faqs.html

STUDIES ON PERTUSSIS:

Waning Tdap Effectiveness in Adults
http://pediatrics.aappublications.org/content/137/3/e20153326?sso=1&sso_redirect_count=1&nfstatus=401&nftoken=00000000-0000-0000-0000-000000000000&nfstatusdescription=ERROR%3a+No+local+token

Acellular pertussis vaccination facilitates Bordetella parapertussis infeciton in a rodent model of bordetellosis (2010)
(Those vaccinated against pertussis are more likely to become infected with parapertussis, which also causes whooping cough but for which there is no vaccine.)
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2880100/

Prevalence and molecular characterization of pertactin-deficient Bordetella pertussis in the United States.
http://www.ncbi.nlm.nih.gov/pubmed/24256623

Baboons vaccinated against whooping cough still spread it to others. (2013)
http://www.pnas.org/content/early/2013/11/20/1314688110
http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm376937.htm

Pertussis infection in the United States: Role for vaccination of adolescents and adults (2006)
http://www.jabfm.org/content/19/6/603.full

The introduction of diphtheria-tetanus-pertussis vaccine and child mortality in rural Guinea-Bissau: an observational study. (Excerpt- “Conclusions: In low-income countries with high mortality, DTP as the last vaccine received may be associated with slightly increased mortality. Since the pattern was inversed for BCG, the effect is unlikely to be due to higher-risk children having received vaccination. The role of DTP in high mortality areas needs to be clarified.”
http://www.ncbi.nlm.nih.gov/pubmed/15082643

Rapid Increase in Pertactin-deficient Bordetella pertussis Isolates, Australia (2014)
http://wwwnc.cdc.gov/eid/article/20/4/13-1478_article.htm

“As many as 800,000-3.3 million cases of pertussis may occur annually in the United States.”
https://www.acoem.org/uploadedFiles/Public_Affairs/Policies_And_Position_Statements/Guidelines/Position_Statements/Pertussis_Vaccination_of_Health_Care_Workers.pdf

“Within the United States, it is estimated that there are between 800,000 and 3.3 million cases per year.”
http://cid.oxfordjournals.org/content/45/11/1487.full#ref-6

“These reported cases may represent the “tip of an iceberg” that consists of 800,000 to 3.3 million cases in the United States every year.”
http://jcm.asm.org/content/50/7/2186.long

“These data suggest that there are between approximately 800,000 and 3.3 million cases per year in the United States.”
http://www.ncbi.nlm.nih.gov/pubmed/15867059

Severe reactions associated with diphtheria-tetanus-pertussis vaccine: detailed study of children with seizures, hypotonic-hyporesponsive episodes, high fevers, and persistent crying. (1993)
http://www.ncbi.nlm.nih.gov/pubmed/8502521

MEDIA COVERAGE ON PERTUSSIS:

Whooping cough protection fades fast after Tdap booster, study finds (2016)
http://www.cnn.com/2016/02/05/health/tdap-whooping-cough-vaccination/

Whooping cough vaccine may not halt spread of illness
http://www.nbcnews.com/health/whooping-cough-vaccine-may-not-halt-spread-illness-2D11655363

Whooping Cough Study May Offer Clue on Surge
http://www.nytimes.com/2013/11/26/health/study-finds-vaccinated-baboons-can-still-carry-whooping-cough.html?_r=0

Whooping cough vaccine may have lost its punch as bacterium evolves
http://www.theguardian.com/world/2014/apr/15/whooping-cough-vaccine-may-have-lost-its-punch-as-bacterium-evolves

First cases of Vaccine-Resistant Whooping Cough Found in United States
http://healthmap.org/site/diseasedaily/article/first-cases-vaccine-resistant-whooping-cough-found-united-states-2813

Whooping Cough May Be Becoming Resistant to Vaccines
http://www.usatoday.com/story/news/health/2013/02/08/whooping-cough-may-be-becoming-resistant-to-vaccines/1903439/

Ascorbic Acid (Vitamin C) Treatment of Whooping Cough (1937)
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1562195/pdf/canmedaj00527-0084.pdf

OTHER:

Dr Suzanne Humphries- The Vitamin C treatment of whooping cough
http://drsuzanne.net/2015/04/the-vitamin-c-treatment-of-whooping-cough-suzanne-humphries-md/

AAP News: Study: Tdap effectiveness declines steadily after first year
http://www.aappublications.org/news/2016/02/08/Tdap020816

Article from thepharmaletter: First Acellular DTP Vaccines Licensed for Infants in USA (1996) (Excerpt: “In the late 1970s, one FDA-funded study conducted at the University of California at Los Angeles discovered that one in 875 vaccinations with whole-cell DTP is followed by a convulsion or collapse/shock. In addition, a large UK study conducted in 1981 found that one in 110,000 DTP vaccinations resulted in a brain inflammation and estimated that one in 310,000 could lead to permanent brain damage.”)
http://www.thepharmaletter.com/article/first-acellular-dtp-vaccine-licensed-for-infants-in-usa

Medscape article: Why the Increase in Pertactin-Deficient Pertussis? (2015)
http://www.medscape.com/viewarticle/842151

Updated recommendations for use of tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis vaccine (Tdap) in pregnant women — Advisory Committee on Immunization Practices (ACIP), 2012.
http://www.ncbi.nlm.nih.gov/pubmed/23425962

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