Pertussis (Whooping Cough)

CDC Pink Book on Pertussis

Package Inserts (DTaP, Tdap)
(DTaP- ages 2 months to 6 years)
(Tdap- ages 7 and up)

Pertussis Information

Pertussis Surveillance and Reporting

Pertussis frequently asked questions


Waning Tdap Effectiveness in Adults

Acellular pertussis vaccination facilitates Bordetella parapertussis infeciton in a rodent model of bordetellosis (2010)
(Those vaccinated against pertussis are more likely to become infected with parapertussis, which also causes whooping cough but for which there is no vaccine.)

Prevalence and molecular characterization of pertactin-deficient Bordetella pertussis in the United States.

Baboons vaccinated against whooping cough still spread it to others. (2013)

Pertussis infection in the United States: Role for vaccination of adolescents and adults (2006)

The introduction of diphtheria-tetanus-pertussis vaccine and child mortality in rural Guinea-Bissau: an observational study. (Excerpt- “Conclusions: In low-income countries with high mortality, DTP as the last vaccine received may be associated with slightly increased mortality. Since the pattern was inversed for BCG, the effect is unlikely to be due to higher-risk children having received vaccination. The role of DTP in high mortality areas needs to be clarified.”

Rapid Increase in Pertactin-deficient Bordetella pertussis Isolates, Australia (2014)

“As many as 800,000-3.3 million cases of pertussis may occur annually in the United States.”

“Within the United States, it is estimated that there are between 800,000 and 3.3 million cases per year.”

“These reported cases may represent the “tip of an iceberg” that consists of 800,000 to 3.3 million cases in the United States every year.”

“These data suggest that there are between approximately 800,000 and 3.3 million cases per year in the United States.”

Severe reactions associated with diphtheria-tetanus-pertussis vaccine: detailed study of children with seizures, hypotonic-hyporesponsive episodes, high fevers, and persistent crying. (1993)


Whooping cough protection fades fast after Tdap booster, study finds (2016)

Whooping cough vaccine may not halt spread of illness

Whooping Cough Study May Offer Clue on Surge

Whooping cough vaccine may have lost its punch as bacterium evolves

First cases of Vaccine-Resistant Whooping Cough Found in United States

Whooping Cough May Be Becoming Resistant to Vaccines

Ascorbic Acid (Vitamin C) Treatment of Whooping Cough (1937)


Dr Suzanne Humphries- The Vitamin C treatment of whooping cough

AAP News: Study: Tdap effectiveness declines steadily after first year

Article from thepharmaletter: First Acellular DTP Vaccines Licensed for Infants in USA (1996) (Excerpt: “In the late 1970s, one FDA-funded study conducted at the University of California at Los Angeles discovered that one in 875 vaccinations with whole-cell DTP is followed by a convulsion or collapse/shock. In addition, a large UK study conducted in 1981 found that one in 110,000 DTP vaccinations resulted in a brain inflammation and estimated that one in 310,000 could lead to permanent brain damage.”)

Medscape article: Why the Increase in Pertactin-Deficient Pertussis? (2015)

Updated recommendations for use of tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis vaccine (Tdap) in pregnant women — Advisory Committee on Immunization Practices (ACIP), 2012.