Diptheria

CDC Pink Book on Diphtheria
http://www.cdc.gov/vaccines/pubs/pinkbook/downloads/dip.pdf

Package Inserts (DTaP, Tdap)
http://www.immunize.org/packageinserts/pi_diphtheria.asp (DTaP- ages 2 months to 6 years)
http://www.immunize.org/packageinserts/pi_tdap.asp (Tdap- ages 7 and up)

Diphtheria Information:
http://www.nvic.org/vaccines-and-diseases/Diphtheria.aspx

Further study (second cases are rare):
http://www.tmb.ie/vaccinations/diphtheria

Information for clinicians, including challenges with diphtheria vaccine:
http://www.cdc.gov/diphtheria/clinicians.html

WHO Vaccine Reactions
http://www.who.int/vaccine_safety/initiative/tools/DTP_vaccine_rates_information_sheet.pdf

History of Vaccines- Timelines: Diphtheria
http://www.historyofvaccines.org/content/timelines/diphtheria

STUDIES:

Guinea pigs given otherwise lethal doses of diphtheria toxin survived when also given ascorbic acid (vitamin C)- animals who died showed depleted levels of vitamin C:
http://www.cabdirect.org/abstracts/19402700950.html;jsessionid=FE4B4EB68C721CEF3C76D2C5A770830F

http://www.jbc.org/content/121/1/31.citation

Guinea pigs treated with vitamin C show increased resistance to diphtheria toxin:
http://ebm.sagepub.com/content/32/7/1157.short

Diphtheria toxin depletes vitamin C:
http://jpet.aspetjournals.org/content/56/2/209.short

Vitamin C intravenously to treat diphtheria (1949):
http://www.seanet.com/~alexs/ascorbate/194x/klenner-fr-southern_med_surg-1949-v111-n7-p209.htm

Diphtheria toxin doesn’t grow well in the presence of iron (1946)
http://www.jbc.org/content/167/1/251.full.pdf

Diphtheria and croup statistics often lumped together (1896)
https://books.google.com/books?id=RFUcAQAAMAAJ&pg=PA353&lpg=PA353&dq=diphtheria+and+croup+statistics&source=bl&ots=Y5BbMUA0ab&sig=WZCyX289PHAljNdyr-qP25CqztM&hl=en&sa=X&ved=0ahUKEwjZ_P6YsYPOAhUExmMKHUOMBq8Q6AEILzAD#v=onepage&q=diphtheria%20and%20croup%20statistics&f=false

The introduction of diphtheria-tetanus-pertussis vaccine and child mortality in rural Guinea-Bissau: an observational study.
(Excerpt- “Conclusions: In low-income countries with high mortality, DTP as the last vaccine received may be associated with slightly increased mortality. Since the pattern was inversed for BCG, the effect is unlikely to be due to higher-risk children having received vaccination. The role of DTP in high mortality areas needs to be clarified.”
http://www.ncbi.nlm.nih.gov/pubmed/15082643

Seroprevalence of diphtheria toxoid IgG antibodies in children, adolescents and adults in Poland.
(Excerpt- “Conclusions: The present study showed inadequate immunity levels to diphtheria amongst the Polish population, especially in adults > 40 years old and children ≤ 2 years old. To prevent reemergence of diphtheria an information campaign reminding people about recommendations concerning diphtheria booster vaccination in adults should be conducted. Moreover, the immunogenicity of the DTP vaccine used in Poland should be verified.”)
http://www.ncbi.nlm.nih.gov/pubmed/24252165

Beijing, China: 50% of population aged 25 and over are not immune, immunity decreases with age (overall positivity rate 66%) with high vaccination rates http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4635875/